Congenital Hypopituitarism due to POU1F1 Gene Mutation
نویسندگان
چکیده
منابع مشابه
Gradual Loss of ACTH Due to a Novel Mutation in LHX4: Comprehensive Mutation Screening in Japanese Patients with Congenital Hypopituitarism
Mutations in transcription factors genes, which are well regulated spatially and temporally in the pituitary gland, result in congenital hypopituitarism (CH) in humans. The prevalence of CH attributable to transcription factor mutations appears to be rare and varies among populations.This study aimed to define the prevalence of CH in terms of nine CH-associated genes among Japanese patients. We...
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BACKGROUND The prevalence of congenital hypopituitarism (CH) attributable to known transcription factor mutations appears to be rare and other causative genes for CH remain to be identified. Due to the sporadic occurrence of CH, de novo chromosomal rearrangements could be one of the molecular mechanisms participating in its etiology, especially in syndromic cases. OBJECTIVE To identify the ro...
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ژورنال
عنوان ژورنال: Journal of the Formosan Medical Association
سال: 2011
ISSN: 0929-6646
DOI: 10.1016/s0929-6646(11)60009-0